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Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis
Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a exper...
متن کاملA randomized, placebo- and active-controlled, parallel-group, multicentre, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis.
BACKGROUND Onychomycosis accounts for up to 50% of all onychopathies. OBJECTIVES To evaluate the efficacy of four posaconazole regimens compared with placebo in the treatment of toenail onychomycosis, to assess the safety and tolerability of posaconazole, and to estimate the relative efficacy of posaconazole against terbinafine. METHODS A phase 2B, randomized, placebo- and active-controlled...
متن کاملActivities of fluconazole in combination with terbinafine against non-albicans Candida species isolated from the patients with recurrent vulvovaginal candidiasis in comparison with ciclopirox olamine
Introduction: Recent epidemiological studies show that episodes due to non-albicans species of Candida (C) such as Candida tropicalis, C. glabrata, C, krusei, C. parapsilosis appear to be increasing in recurrent vulvovaginal candidiasis (RVVC). Increased use of the current antifungal drugs cause drug resistance among Candida species. In order to gain suitable antifungal therapy for this disease...
متن کاملIn Vitro Comparison of MIC Crude Extracts of Active Actinomycetes Isolated with Terbinafine, Griseofulvin Ketoconazole and Fluconazole against Microsporum Canis, Microsporum Gypseum and Trichophyton Mentagrophytes
Abstract Background and Objective: Dermatophytes are the fungi that have the ability to attack the keratinized tissues such as the skin, hair and nails. Infections caused by these organisms are named dermatophytosis. We aimed to compare Minimum inhibitory concentration (MIC) of Crude extracts of Active Actinomycete Isolates with Terbinafine, Griseofulvin, Ketoconazole and Fluconazole Drugs ...
متن کاملConfluent and reticulate papillomatosis: response to topical terbinafine and oral fluconazole; a case report
Confluent and Reticulate Papillomatosis (CRP) is a rare disease withpoorly recognized etiology. Various agents such as antibacterial,topical/systemic antifungal and topical/oral retinoids have beenused as treatment. Here, we report a 15-year-old female withCRP in whom yeasts of Malassezia were found in the PAS stainof the skin lesions. Topical terbinafine hydrochloride 1% sprayand oral fluconaz...
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